Does Medicare Cover Ketamine Treatments?

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Russell Noga
by Russell Noga | Updated February 12th, 2024

The short answer to ‘does Medicare cover ketamine’ is not straightforward. While Medicare does cover certain FDA-approved ketamine treatments like Spravato for depression, traditional ketamine infusions generally don’t make the cut. This article zeroes in on when and how Medicare coverage applies to ketamine therapy and other financial considerations you might face.


Key Takeaways

  • Medicare currently covers the FDA-approved esketamine (Spravato) for treatment-resistant depression under specific conditions but does not extend coverage to generic ketamine infusions for the same purpose.
  • Ketamine therapy, while effective for various psychiatric disorders and chronic pain, is largely not covered by insurance, leading to high out-of-pocket expenses for patients; strategies like submitting a Superbill can help appeal for reimbursements.
  • The future of Medicare coverage for ketamine treatments could change with advocacy efforts, pending legislation, and the potential FDA approval of new uses and delivery methods for ketamine.


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Ketamine Therapy: An Overview


Ketamine Therapy An Overview


Ketamine therapy, often administered through intravenous infusion, is revolutionizing treatment for psychiatric disorders and chronic pain management. This treatment method, once known primarily as an anesthetic, has proven effective against:

  • major depressive disorder
  • bipolar disorder
  • PTSD
  • chronic pain

especially when traditional treatments have failed.

Administered in a clinical setting, ketamine therapy involves a series of infusions, carried out with stringent safety protocols, including health screenings and patient monitoring. The therapy targets brain receptors, promoting neurochemical communication and synaptic regeneration, which can quickly alleviate depression and modulate pain perception.

The safety profile of ketamine therapy includes manageable side effects such as dissociation and temporary increases in blood pressure. Its high efficacy, coupled with the rapid relief it offers for mood disorders and pain, positions it as a promising treatment method.

Medicare and Ketamine Infusions: The Coverage Landscape

Currently, Medicare provides coverage for the FDA-approved esketamine, known as Spravato, when prescribed by a doctor for treatment-resistant depression. However, keep in mind that certain conditions must be fulfilled to be eligible for coverage.

Patients must meet the following criteria for depression treatment:

  • Have a diagnosis of treatment-resistant depression
  • Have tried at least two other antidepressants without success
  • Meet other criteria determined by a healthcare provider

Despite these conditions, the current coverage landscape does not extend to generic ketamine infusions.


The Role of FDA Approval in Medicare Coverage

Medicare’s decision to provide coverage is significantly influenced by the FDA’s approval of medications and treatments. For instance, esketamine received FDA approval for use as Spravato, leading to its coverage under Medicare Part D for eligible patients. These approval and coverage decisions significantly impact the cost and insurance coverage of ketamine treatment.


Understanding Part D and Medicare Advantage Plans

Medicare Advantage (MA) offers an alternative to Original Medicare, providing a bundled option for both hospital and medical insurance. Distinct from Original Medicare, MA plans usually include prescription drug benefits and may offer additional benefits not covered by Medicare Parts A and B.

Certain treatments, like off-label use of ketamine therapy, may require prior authorization under MA plans. To obtain coverage, patients generally need to submit a detailed medical history, which can impact the outcome of their coverage request.



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Navigating Insurance: Ketamine Treatment Costs and Reimbursement

Despite its effectiveness, ketamine is not FDA-approved for treating depression and is typically not covered by insurance, often leading to out-of-pocket payments. However, insurance may cover some associated costs, such as doctor visits integral to ketamine therapy, despite not covering the infusions themselves.

The total cost of ketamine infusion therapy averages around $4,500, with individual infusions ranging between $450 and $500. However, patients with PPO plans can receive higher reimbursement for out-of-network services compared to those with HMO plans, which typically don’t offer out-of-network benefits.


Strategies for Seeking Reimbursement

Patients can obtain a Superbill – a detailed list of services and codes, to appeal coverage denials and seek reimbursement for out-of-pocket expenses for ketamine therapy. A well-supported appeal, backed by documentation such as proof of ineffectiveness of traditional therapies, may enhance the likelihood of a successful reimbursement claim.


Alternative Payment Options

For patients ineligible for Medicare coverage, several alternative payment options can help manage ketamine treatment costs. These include:

  • Using Health Savings Account (HSA) or Flexible Spending Account (FSA)
  • Installment payment plans offered by healthcare providers
  • Medical financing options such as Advance Care

Comparing Ketamine to Other Depression Treatments

Comparing Ketamine to Other Depression Treatments


Compared to traditional antidepressants, ketamine therapy shows superior effectiveness and faster relief from depressive symptoms. In fact, it’s generally safe to use ketamine along with:

  • SSRIs
  • SNRIs
  • Wellbutrin
  • lithium

But combining it with MAOIs can pose risks like increased heart rate and blood pressure.

However, antipsychotic medications prescribed for bipolar depression can reduce the effectiveness of ketamine treatments. Also, while other alternative treatments like Electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS) exist for major depressive disorder and treatment-resistant depression, they come with their own limitations. ECT can result in memory loss, and TMS requires a lengthy treatment schedule.

Despite these comparisons, bear in mind that Medicare cover ketamine when used as an anesthetic, but not when it’s used as generic ketamine for mental health disorders. However, Medicare cover ketamine infusions, and in some cases, Medicare cover ketamine therapy in the form of FDA-approved treatments like Esketamine (Spravato).

Mental Health Conditions and Insurance Coverage

Medicare covers ketamine therapy for the treatment of major depressive disorder and treatment-resistant depression. This treatment can provide relief for those suffering from these conditions. This provides relief for many patients, especially seniors and women who tend to be more affected by treatment-resistant depression, and may find relief in ketamine therapy, particularly when linked to brain inflammation.

Despite the potential side effects such as dissociation, dizziness, and elevated blood pressure, the efficacy of esketamine, known as Spravato, in treating depression has been observed in 40-60% of cases based on treatment duration.

Generic ketamine, when used off-label, is typically not covered by most major insurance companies. This can limit access to the medication for some patients. The growing body of evidence and ongoing research data publication on ketamine treatments, however, might influence future coverage policies.

The Future of Ketamine Coverage

The Future of Ketamine Coverage


Advocacy groups are advocating for a broader insurance coverage for ketamine treatments in the future, including under Medicare. Moreover, pending legislation could direct Medicare to cover ketamine treatments for depression, signaling a potential shift in policy.

Future coverage of ketamine could be influenced by:

  • Modifications to the FDA’s list of approved uses for ketamine
  • Approval of new delivery methods
  • Results of ongoing clinical trials and peer-reviewed research

These factors are expected to play a significant role in determining future coverage of ketamine by insurance providers, including Medicare.


In conclusion, ketamine therapy presents a promising treatment for psychiatric disorders and chronic pain, yet its coverage under Medicare and insurance providers remains limited. While some progress has been made, with FDA-approved esketamine (Spravato) being covered under certain conditions, generic ketamine infusions remain largely out-of-pocket expenses. As research advances and advocacy efforts continue, we can remain hopeful for broader coverage in the future. Stay informed, stay hopeful.

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Frequently Asked Questions

Does Medicare cover ketamine therapy?

No, Medicare does not cover generic ketamine infusions, but it covers FDA-approved esketamine (Spravato) for treatment-resistant depression under specific conditions.


What is the cost of ketamine therapy?

Ketamine infusion therapy typically costs around $4,500 in total, with individual infusions ranging from $450 to $500.


Are there alternative payment options for ketamine therapy?

Yes, patients have alternative payment options for ketamine therapy, including using their Health Savings Account (HSA) or Flexible Spending Account (FSA) or installment payment plans offered by healthcare providers. These options can help make the therapy more financially manageable for patients.


Is ketamine therapy more effective than traditional antidepressants?

Yes, ketamine therapy is more effective and provides faster relief from depressive symptoms compared to traditional antidepressants.


Speak to the Professionals about Medigap Plans and Original Medicare

If you find understanding the benefits involved with Original Medicare and Medigap Plans challenging, you’re not alone. Whether it’s a Medigap plan, or you want to know more about Medicare coverage for Ketamine treatment, we can help. Call our team at 1-888-891-0229 for a free consultation or complete the contact form on this site, and an expert will call you back at a convenient time.

We have decades of experience advising our clients on the complexities of Medicare and Medigap plans, the benefits, cost and deductibles. We’ll ensure you get the best rate in your state and advice you can trust.

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